UPDATE: 3:15 p.m.
State Police said at least two people have died after the accident on I-81 around 11:15 a.m. Wednesday.
Police said two other people were flown from the scene with life-threatening injuries.
They said the road is still blocked and will remain blocked until reconstruction is completed, which could be another hour.
VDOT is detouring southbound traffic off the Interstate at the 141 exit.
The 140 southbound entrance ramp is also blocked to keep traffic from the scene of the crash.
All traffic is diverted to Route 11 and may get back on the Interstate at Exit 137.
For more information from ABC-13 WSET, click HERE.